Authors:
TK Leslie, AD James, F Zaccagna, JT Grist, S Deen, A Kennerley, F Riemer, JD Kaggie, FA Gallagher, FJ Gilbert, WJ Brackenbury
Journal name: 
Biochim Biophys Acta Rev Cancer
Abstract: 
The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requires a large proportion of the cell's ATP. Na+ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell volume and metabolism as well as immune function. Here, we review evidence indicating that Na+ handling is altered in tumours, explore our current understanding of the mechanisms that may underlie these alterations and consider the potential consequences for cancer progression. Dysregulated Na+ balance in tumours may open opportunities for new imaging biomarkers and re-purposing of drugs for treatment.
DOI: 
http://doi.org/10.1016/j.bbcan.2019.07.001
E-pub date: 
30 Jun 2019
Users with this publication listed: 
Ferdia Gallagher