Authors:
A Bugaut, R Rodriguez, S Kumari, S-TD Hsu, S Balasubramanian
Journal name: 
Org Biomol Chem
Citation info: 
8(12):2771-2776
Abstract: 
Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.
DOI: 
http://doi.org/10.1039/c002418j
Research group: 
Balasubramanian Group
E-pub date: 
21 Jun 2010