Authors:
PS Shirude, S Balasubramanian
Journal name: 
Biochimie
Citation info: 
90(8):1197-1206
Abstract: 
Single molecule fluorescence resonance energy transfer (FRET) can be employed to study conformational heterogeneity and real-time dynamics of biological macromolecules. Here we present single molecule studies on human genomic DNA G-quadruplex sequences that occur in the telomeres and in the promoter of a proto-oncogene. The findings are discussed with respect to the proposed biological function(s) of such motifs in living cells.
DOI: 
http://doi.org/10.1016/j.biochi.2008.01.015
Research group: 
Balasubramanian Group
E-pub date: 
31 Aug 2008