Authors:
ASL Chan, M Narita
Journal name: 
Genes Dev
Citation info: 
33(3-4):127-143
Abstract: 
Originally thought of as a stress response end point, the view of cellular senescence has since evolved into one encompassing a wide range of physiological and pathological functions, including both protumorignic and antitumorigenic features. It has also become evident that senescence is a highly dynamic and heterogenous process. Efforts to reconcile the beneficial and detrimental features of senescence suggest that physiological functions require the transient presence of senescent cells in the tissue microenvironment. Here, we propose the concept of a physiological "senescence life cycle," which has pathological consequences if not executed in its entirety.
DOI: 
http://doi.org/10.1101/gad.320937.118
Research group: 
Narita Group
E-pub date: 
31 Jan 2019
Users with this publication listed: 
Adelyne Chan
Andrew Young
Masashi Narita