Authors:
M Habibian, S Martínez-Montero, G Portella, Z Chua, DS Bohle, M Orozco, MJ Damha
Journal name: 
Org Lett
Citation info: 
17(21):5416-5419
Abstract: 
The synthesis of a novel series of seven-membered ring nucleoside analogues as candidates for biological screening and gene silencing applications is described. The key step in the synthetic approach is a stereoselective synthesis of an epoxide that is used as a common synthetic intermediate to prepare functionalized oxepane nucleoside derivatives. The conformational landscape and preferred ring-puckering of selected oxepane nucleosides was also studied by NMR, X-ray crystallography, and quantum mechanical calculations.
DOI: 
http://doi.org/10.1021/acs.orglett.5b02769
E-pub date: 
06 Nov 2015