Authors:
SE Oliver, B Barrass, DJ Gunnell, JL Donovan, TJ Peters, RA Persad, D Gillatt, DE Neal, FC Hamdy, JMP Holly
Journal name: 
Cancer Epidemiol Biomarkers Prev
Citation info: 
13(1):163-165
Abstract: 
We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.
DOI: 
http://doi.org/10.1158/1055-9965.epi-03-0102
E-pub date: 
01 Jan 2004
Users with this publication listed: 
David Neal