Authors:
Y Nakatani, HK Opel-Reading, M Merker, D Machado, S Andres, SS Kumar, D Moradigaravand, F Coll, J Perdigão, I Portugal, T Schön, D Nair, KRU Devi, TA Kohl, P Beckert, TG Clark, G Maphalala, D Khumalo, R Diel, K Klaos, HL Aung, GM Cook, J Parkhill, SJ Peacock, S Swaminathan, M Viveiros, S Niemann, KL Krause, CU Köser
Journal name: 
Antimicrob Agents Chemother
Citation info: 
61(12)
Abstract: 
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
DOI: 
http://doi.org/10.1128/AAC.01575-17
E-pub date: 
31 Dec 2017