Authors:
SG Spiro, A Hackshaw, LungSEARCH Collaborative Group
Journal name: 
Thorax
Citation info: 
71(1):91-93
Abstract: 
UNLABELLED: Low-dose CT screening for lung cancer is effective but expensive. Therefore, cheaper or more focused screening strategies may be required. LungSEARCH is a randomised prospective trial of 1568 high-risk individuals (ie, current or former moderate to heavy smokers with mild/moderate COPD) who undergo either annual sputum cytology/cytometry testing or no screening. Those with abnormal sputum then receive annual CT and fluorescent bronchoscopy for the remainder of 5 years, to identify early stage lung cancer. It is hoped that these simple initial tests could identify those requiring expensive CT scans, and the aim is to demonstrate a stage shift towards early stage cancers.Trial registration numbers ISRCTN: ISRCTN80745975, clinicaltrials.gov: NCT00512746.
DOI: 
http://doi.org/10.1136/thoraxjnl-2015-207433
E-pub date: 
31 Jan 2016