Authors:
MAA Castro, X Wang, MNC Fletcher, KB Meyer, F Markowetz
Journal name: 
Genome Biol
Citation info: 
13(4):R29
Abstract: 
Visualization and analysis of molecular networks are both central to systems biology. However, there still exists a large technological gap between them, especially when assessing multiple network levels or hierarchies. Here we present RedeR, an R/Bioconductor package combined with a Java core engine for representing modular networks. The functionality of RedeR is demonstrated in two different scenarios: hierarchical and modular organization in gene co-expression networks and nested structures in time-course gene expression subnetworks. Our results demonstrate RedeR as a new framework to deal with the multiple network levels that are inherent to complex biological systems. RedeR is available from http://bioconductor.org/packages/release/bioc/html/RedeR.html.
DOI: 
http://doi.org/10.1186/gb-2012-13-4-r29
Research group: 
Markowetz Group
E-pub date: 
24 Apr 2012