J Weaver, C Ross-Innes, N Shannon, A Lynch, M Murtaza, T Forshew, M Dunning, T Underwood, R Hardwick, M Eldridge, P Edwards, N Rosenfeld, S Tavare, R Fitzgerald, Occams, ICGC Oesophageal Adenocarcinoma consortium
63 Suppl 1:A105-A106
A series of clonal expansions are thought to underlie the progression of Barrett's oesophagus (BE) to oesophageal adenocarcinoma (OAC). Each expansion carries with it somatic driver mutation (s) fixing it within a larger population and therefore increasing the likelihood of acquiring a second mutation. However, the precise order in which somatic variants occur remains unknown.