Authors:
DJ Winton, MA Blount, BA Ponder
Journal name: 
Br J Cancer
Citation info: 
60(1):59-63
Abstract: 
We show that, from the earliest morphologically recognisable stages of development, mouse skin papillomas induced by a chemical initiation-promotion regime are polyclonal. We have demonstrated polyclonality directly by immunohistochemical staining of the mosaic cell populations in embryo aggregation chimaeras, a method which removes some of the uncertainties of previous conclusions based on analysis using electrophoretic polymorphisms. The findings may imply that initiation within a single cell and promotion of its clonal descendents is not a sufficient explanation for the origin of these tumours and that interaction between cells of more than one clone is involved.
DOI: 
http://doi.org/10.1038/bjc.1989.220
Research group: 
Ponder Group, Winton Group
E-pub date: 
01 Jul 1989
Users with this publication listed: 
Bruce Ponder
Doug Winton