Authors:
P Sun, P Dong, K Dai, GJ Hannon, D Beach
Journal name: 
Science
Citation info: 
282(5397):2270-2272
Abstract: 
Transforming growth factor-beta (TGF-beta) inhibits cell proliferation, and acquisition of TGF-beta resistance has been linked to tumorigenesis. A genetic screen was performed to identify complementary DNAs that abrogated TGF-beta sensitivity in mink lung epithelial cells. Ectopic expression of murine double minute 2 rescued TGF-beta-induced growth arrest in a p53-independent manner by interference with retinoblastoma susceptibility gene product (Rb)/E2F function. In human breast tumor cells, increased MDM2 expression levels correlated with TGF-beta resistance. Thus, MDM2 may confer TGF-beta resistance in a subset of tumors and may promote tumorigenesis by interference with two independent tumor suppressors, p53 and Rb.
DOI: 
http://doi.org/10.1126/science.282.5397.2270
Research group: 
Hannon Group
E-pub date: 
30 Nov 1998
Users with this publication listed: 
Greg Hannon