H Zhang, GJ Hannon, D Beach
Journal name: 
Genes Dev
Citation info: 
In normal fibroblasts CDKs exist predominantly in p21/PCNA/cyclin/CDK quaternary complexes, whereas in p53-deficient cells, p21 expression is depressed and the kinases are reduced to a cyclin/CDK binary state. p21 is a universal cyclin kinase inhibitor, but we show here that p21-containing complexes exist in both catalytically active and inactive forms. This finding challenges the current view that active cyclin kinases function only in the binary state and reveals the subtlety with which tumor-suppressor proteins modulate the cell cycle.
Research group: 
Hannon Group
E-pub date: 
31 Jul 1994
Users with this publication listed: 
Greg Hannon