Authors:
M de la Roche, Y Asano, GM Griffiths
Journal name: 
Nat Rev Immunol
Citation info: 
16(7):421-432
Abstract: 
Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell, and marked reorganization of both the actin and the microtubule cytoskeletons brings the centrosome up to the plasma membrane to the point of T cell receptor signalling. Secretory granules move towards the centrosome and are delivered to this focal point of secretion. Such centrosomal docking at the plasma membrane also occurs during ciliogenesis; indeed, striking similarities exist between the cytolytic synapse and the primary cilium that throw light on the possible origins of immune synapses.
DOI: 
http://doi.org/10.1038/nri.2016.54
Research group: 
de la Roche Group
E-pub date: 
31 Jul 2016