Authors:
LN Maslov, EI Barzakh, AV Krylatov, GA Chernysheva, T Krieg, NV Solenkova, AY Lishmanov, SY Cybulnikov, Y Zhang
Journal name: 
Bull Exp Biol Med
Citation info: 
149(5):591-593
Abstract: 
The cardioprotective properties of a δ₂-opioid receptor agonist deltorphin II were studied in rats with coronary occlusion and reperfusion. Opioid receptor ligands and inhibitors (glybenclamide, chelerythrine, and 5-hydroxydecanoate) were injected intravenously before ischemia and reperfusion. A δ₂-opioid receptor agonist deltorphin II significantly decreased the infarction zone/risk zone index. This effect was abolished by naltrexone, naloxone methiodide, and δ₂-opioid receptor antagonist naltriben, but not by a δ₁-opioid receptor antagonist BNTX. The infarct-limiting effect of deltorphin II was not observed after inhibition of protein kinase C or blockade of mitochondrial K(ATP) channels.
DOI: 
http://doi.org/10.1007/s10517-010-1000-6
E-pub date: 
01 Oct 2010
Users with this publication listed: 
Thomas Krieg