Authors:
SM Janes, FM Watt
Journal name: 
Nat Rev Cancer
Citation info: 
6(3):175-183
Abstract: 
Although integrins are known to mediate invasion and metastasis, recent studies reveal new ways in which they contribute to squamous-cell carcinoma. Integrin mutation or upregulation can expand the tumour stem-cell compartment by inhibiting differentiation or apoptosis. Integrins that are expressed by differentiated cells can stimulate or inhibit the proliferation of neighbouring tumour stem cells. These findings provide a mechanistic basis for the well-established links between altered integrin expression and tumour prognosis.
DOI: 
http://doi.org/10.1038/nrc1817
Research group: 
Watt Group
E-pub date: 
01 Mar 2006