Authors:
JD Bernstock, L Peruzzotti-Jametti, D Ye, FA Gessler, D Maric, N Vicario, Y-J Lee, S Pluchino, JM Hallenbeck
Journal name: 
J Cereb Blood Flow Metab
Citation info: 
37(7):2314-2319
Abstract: 
Ischemic stroke continues to be a leading cause of morbidity and mortality throughout the world. To protect and/or repair the ischemic brain, a multitiered approach may be centered on neural stem cell (NSC) transplantation. Transplanted NSCs exert beneficial effects not only via structural replacement, but also via immunomodulatory and/or neurotrophic actions. Unfortunately, the clinical translation of such promising therapies remains elusive, in part due to their limited persistence/survivability within the hostile ischemic microenvironment. Herein, we discuss current approaches for the development of NSCs more amenable to survival within the ischemic brain as a tool for future cellular therapies in stroke.
DOI: 
http://doi.org/10.1177/0271678X17700432
E-pub date: 
31 Jul 2017