Authors:
KA de Foy, SA Gayther, WH Colledge, S Crockett, IV Scott, MJ Evans, BA Ponder
Journal name: 
Br J Cancer
Citation info: 
77(10):1642-1644
Abstract: 
Female transgenic mice lacking a functional c-mos proto-oncogene develop ovarian teratomas, indicating that c-mos may behave as a tumour-suppressor gene for this type of tumour. We have analysed the entire coding region of the c-MOS gene in a series of human ovarian teratomas to determine whether there are any cancer-causing alterations. DNA from twenty teratomas was analysed by single-strand conformational analysis (SSCA) and heteroduplex analysis (HA) to screen for somatic and germline mutations. In nine of these tumours the entire gene was also sequenced. A previously reported polymorphism and a single new sequence variant were identified, neither of which we would predict to be disease-causing alterations. These results suggest that mutations in the coding region of the c-MOS gene do not play a significant role in the genesis of human ovarian teratomas.
DOI: 
http://doi.org/10.1038/bjc.1998.269
Research group: 
Ponder Group
E-pub date: 
01 May 1998
Users with this publication listed: 
Bruce Ponder