Authors:
C Eng, KA Foster, CS Healey, C Houghton, SA Gayther, LM Mulligan, BA Ponder
Journal name: 
Br J Cancer
Citation info: 
74(3):339-341
Abstract: 
The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We carried out direct sequence analysis of human c-mos and human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations are detected. No somatic mutations were found.
DOI: 
http://doi.org/10.1038/bjc.1996.363
Research group: 
Ponder Group
E-pub date: 
31 Aug 1996
Users with this publication listed: 
Bruce Ponder