Authors:
MP d'Ortho, H Stanton, M Butler, SJ Atkinson, G Murphy, RM Hembry
Journal name: 
FEBS Lett
Citation info: 
421(2):159-164
Abstract: 
The membrane-type matrix metalloproteinases (MT-MMPs) are a subclass of the matrix metalloproteinase (MMP) family which uniquely possess a C-terminal transmembrane domain and are initiators of an activation cascade for progelatinase A (MMP-2). Recent studies have shown that they can also efficiently directly degrade a number of matrix macromolecules. We now show that cells expressing MT1-MMP on their cell surfaces cause subjacent proteolysis of a gelatin film and that this proteolysis is inhibited by TIMP-2 but not by TIMP-1. These data indicate that expression of MT1-MMP on the cell surface may lead to both progelatinase A activation and extracellular matrix degradation.
DOI: 
http://doi.org/10.1016/s0014-5793(97)01555-x
E-pub date: 
31 Dec 1997
Users with this publication listed: 
Gillian Murphy