Authors:
KA Serban, I Petrache
Citation info: 
1809:379-394
Abstract: 
Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their implementation. E-cigarettes are an emerging health concern and may also contribute to lung disease. Accordingly, approaches to study e-cigarette vapors are provided. This chapter also includes methods and tools necessary to assess lung morphologic and functional changes in animals with emphysema-like airspace enlargement.
DOI: 
http://doi.org/10.1007/978-1-4939-8570-8_25
Research group: 
Narita Group
E-pub date: 
01 Aug 2018
Users with this publication listed: 
Masashi Narita