F Gergely
Journal name: 
Curr Biol
Citation info: 
The two co-activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitination by the core complex, but their role in conferring substrate specificity has been contentious. A new report reveals that Cdc20-bound APC/C initiates the timely proteolysis of many Cdh1 substrates with the exception of the Aurora kinases. Failure to degrade Aurora kinases results in abnormal anaphase microtubule organisation and premature cytokinesis.
Research group: 
Gergely Group
E-pub date: 
11 Nov 2008
Users with this publication listed: 
Fanni Gergely