Authors:
F Gergely
Journal name: 
Curr Biol
Citation info: 
18(21):R1009-R1012
Abstract: 
The two co-activators of the anaphase-promoting complex/cyclosome (APC/C), Cdc20 and Cdh1, facilitate ubiquitination by the core complex, but their role in conferring substrate specificity has been contentious. A new report reveals that Cdc20-bound APC/C initiates the timely proteolysis of many Cdh1 substrates with the exception of the Aurora kinases. Failure to degrade Aurora kinases results in abnormal anaphase microtubule organisation and premature cytokinesis.
DOI: 
http://doi.org/10.1016/j.cub.2008.08.037
Research group: 
Gergely Group
E-pub date: 
11 Nov 2008