Authors:
L He, X He, SW Lowe, GJ Hannon
Journal name: 
Nat Rev Cancer
Citation info: 
7(11):819-822
Abstract: 
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
DOI: 
http://doi.org/10.1038/nrc2232
Research group: 
Hannon Group
E-pub date: 
01 Nov 2007