Authors:
J Le Quesne, C Caldas
Journal name: 
Mol Oncol
Citation info: 
4(3):230-241
Abstract: 
Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding RNA molecules, which primarily act by down-regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour-suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer.
DOI: 
http://doi.org/10.1016/j.molonc.2010.04.009
Research group: 
Caldas Group
E-pub date: 
01 Jun 2010