Authors:
R Wooster, SL Neuhausen, J Mangion, Y Quirk, D Ford, N Collins, K Nguyen, S Seal, T Tran, D Averill
Journal name: 
Science
Citation info: 
265(5181):2088-2090
Abstract: 
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
DOI: 
http://doi.org/10.1126/science.8091231
Research group: 
Ponder Group
E-pub date: 
31 Aug 1994
Users with this publication listed: 
Bruce Ponder