Authors:
G Shi, MA Perle, K Mittal, H Chen, X Zou, M Narita, E Hernando, P Lee, J-J Wei
Journal name: 
J Cell Mol Med
Citation info: 
13(9B):3898-3905
Abstract: 
Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart - uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and let-7s play a role in ULMS, we examined the levels of endogenous HMGA2 and let-7 expression and found a significant correlation between these two molecules in a case-matched cohort of human ULMS. We found that overexpression of HMGA2 and let-7-mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro.
DOI: 
http://doi.org/10.1111/j.1582-4934.2008.00541.x
Research group: 
Narita Group
E-pub date: 
01 Sep 2009