Authors:
SA Popova, SJA Buczacki
Journal name: 
Mol Cell Oncol
Citation info: 
5(4):e1494950
Abstract: 
Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.
DOI: 
http://doi.org/10.1080/23723556.2018.1494950
Research group: 
Tavaré Group, Light Microscopy
E-pub date: 
01 Aug 2018