Authors:
JG Harrison, C Frier, R Laurant, R Dennis, KD Raney, S Balasubramanian
Journal name: 
Bioorg Med Chem Lett
Citation info: 
9(9):1273-1278
Abstract: 
The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.
DOI: 
http://doi.org/10.1016/s0960-894x(99)00170-5
Research group: 
Balasubramanian Group
E-pub date: 
30 Apr 1999
Users with this publication listed: 
Shankar Balasubramanian