Authors:
ED Williams, BJ Ponder, RK Craig
Journal name: 
Clin Endocrinol (Oxf)
Citation info: 
27(1):107-114
Abstract: 
The distribution of calcitonin and calcitonin gene-related peptide (CGRP) has been studied by immunohistochemistry in normal, hyperplastic and neoplastic C cells. Fewer normal C cells contained immunoreactive CGRP than calcitonin, though both peptides can be co-expressed by a single cell. In the hyperplastic C cells that accompany familial medullary carcinoma immunohistochemistry was strongly and diffusely positive for both CGRP and calcitonin. In contrast, in medullary carcinoma, whether sporadic or familial, little CGRP was identified; often only a few strongly positive cells were found in a negative background, while immunoreactive calcitonin was commonly present in large amounts. The findings suggest that CGRP immunohistochemistry may be of value in identifying hyperplastic C cells, and that CGRP levels should be studied in medullary carcinoma families.
DOI: 
http://doi.org/10.1111/j.1365-2265.1987.tb00845.x
Research group: 
Ponder Group
E-pub date: 
01 Jul 1987
Users with this publication listed: 
Bruce Ponder