Authors:

AL Jackman, DI Jodrell, W Gibson, TC Stephens

Journal name: 

Adv Exp Med Biol

Citation info: 

309A:19-23

Abstract: 

The TS inhibitor, ICI D1694, is a highly potent inhibitor of tumour growth in vitro and in vivo. Uptake via the RFC and rapid metabolism to polyglutamate forms appear to be responsible for potency. Antiproliferative toxicity in mice was evident although the dose-limiting renal toxicity experienced with CB3717 was not apparent.

DOI: 

http://doi.org/10.1007/978-1-4899-2638-8_4

Research group: 

Jodrell Group

E-pub date: 

01 Aug 1991

Users with this publication listed: 

Duncan Jodrell