Authors:
AL Jackman, DI Jodrell, W Gibson, TC Stephens
Journal name: 
Adv Exp Med Biol
Citation info: 
309A:19-23
Abstract: 
The TS inhibitor, ICI D1694, is a highly potent inhibitor of tumour growth in vitro and in vivo. Uptake via the RFC and rapid metabolism to polyglutamate forms appear to be responsible for potency. Antiproliferative toxicity in mice was evident although the dose-limiting renal toxicity experienced with CB3717 was not apparent.
DOI: 
http://doi.org/10.1007/978-1-4899-2638-8_4
Research group: 
Jodrell Group
E-pub date: 
01 Aug 1991
Users with this publication listed: 
Duncan Jodrell