Authors:
M Mishkovsky, A Comment
Journal name: 
Anal Biochem
Citation info: 
529:270-277
Abstract: 
The advent of dissolution dynamic nuclear polarization (DNP) led to the emergence of a new kind of magnetic resonance (MR) measurements providing the opportunity to probe metabolism in vivo in real time. It has been shown that, following the injection of hyperpolarized substrates prepared using dissolution DNP, specific metabolic bioprobes that can be used to differentiate between healthy and pathological tissue in preclinical and clinical studies can be readily detected by MR thanks to the tremendous signal enhancement. The present article aims at reviewing the studies of cerebral function and metabolism based on the use of hyperpolarized MR. The constraints and future opportunities that this technology could offer are discussed.
DOI: 
http://doi.org/10.1016/j.ab.2016.09.020
E-pub date: 
30 Jun 2017
Users with this publication listed: 
Arnaud Comment