Authors:
H Takeda, S Lyle, AJF Lazar, CC Zouboulis, I Smyth, FM Watt
Journal name: 
Nat Med
Citation info: 
12(4):395-397
Abstract: 
We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to beta-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.
DOI: 
http://doi.org/10.1038/nm1386
Research group: 
Watt Group
E-pub date: 
01 Apr 2006