A Jiménez-Sánchez, D Memon, S Pourpe, H Veeraraghavan, Y Li, HA Vargas, MB Gill, KJ Park, O Zivanovic, J Konner, J Ricca, D Zamarin, T Walther, C Aghajanian, JD Wolchok, E Sala, T Merghoub, A Snyder, ML Miller
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Citation info: 
We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases were infiltrated by CD8+ and CD4+ T cells and exhibited oligoclonal expansion of specific T cell subsets. We also detected CD8+ T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy. VIDEO ABSTRACT.
Research group: 
Miller Group
E-pub date: 
24 Aug 2017
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Alejandro Jimenez Sanchez
Evis Sala
Martin Miller