Authors:
TYF Halim, YY Hwang, ST Scanlon, H Zaghouani, N Garbi, PG Fallon, ANJ McKenzie
Journal name: 
Nat Immunol
Citation info: 
17(1):57-64
Abstract: 
Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses, with targeted depletion of ILC2 cells profoundly impairing TH2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs). Consequently, the sentinel function of DCs is contingent on ILC2 cells for the generation of an efficient memory TH2 cell response. These results elucidate a key innate mechanism in the regulation of the immune memory response to allergens.
DOI: 
http://doi.org/10.1038/ni.3294
Research group: 
Halim Group
E-pub date: 
31 Jan 2016