Authors:
DD Le, M Di Antonio, LKM Chan, S Balasubramanian
Journal name: 
Chem Commun (Camb)
Citation info: 
51(38):8048-8050
Abstract: 
A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.
DOI: 
http://doi.org/10.1039/c5cc02252e
Research group: 
Balasubramanian Group
E-pub date: 
11 May 2015