Authors:
PV Jena, PS Shirude, B Okumus, K Laxmi-Reddy, F Godde, I Huc, S Balasubramanian, T Ha
Journal name: 
J Am Chem Soc
Citation info: 
131(35):12522-12523
Abstract: 
Using single molecule fluorescence resonance energy transfer, we investigated the interaction between a quadruplex-binding ligand and the human telomeric G-quadruplex. The binding of quinolinecarboxamide macrocycle to telomeric DNA was essentially irreversible and selectively induced and favored one quadruplex conformation. The ligand-quadruplex complex displayed intramolecular dynamics including quadruplex folding and unfolding in the absence of ligand association and dissociation. We report that the G-quadruplex can be stabilized without preventing the intrinsic intramolecular dynamics of telomeric DNA.
DOI: 
http://doi.org/10.1021/ja903408r
Research group: 
Balasubramanian Group
E-pub date: 
09 Sep 2009