M Tran, A Latifoltojar, JB Neves, M-V Papoutsaki, F Gong, A Comment, ASH Costa, M Glaser, M-A Tran-Dang, S El Sheikh, W Piga, A Bainbridge, A Barnes, T Young, H Jeraj, R Awais, S Adeleke, C Holt, J O'Callaghan, F Twyman, D Atkinson, C Frezza, E Årstad, D Gadian, M Emberton, S Punwani
Journal name: 
BJR Case Rep
Citation info: 
Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma (RCC) have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of RCC using hyperpolarized carbon-13 (13C) magnetic resonance imaging (HP-MRI) and describe the validation of in vivo lactate metabolic heterogeneity against multi-regional ex vivo mass spectrometry. HP-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.
E-pub date: 
30 Apr 2019
Users with this publication listed: 
Arnaud Comment