Authors:
MD Wilson, DT Odom
Journal name: 
Curr Opin Genet Dev
Citation info: 
19(6):579-585
Abstract: 
Changes in gene expression directed by transcriptional regulators can give rise to new phenotypes. While gene expression profiles can be maintained across large evolutionary distances, transcription factor-DNA interactions diverge rapidly. The application of new genome-wide methodologies has begun refining our global understanding of when and where mammalian transcription factors interact with DNA, thereby providing new insight into the mechanisms of transcriptional evolution. The interplay between cis and trans regulation of gene expression is an increasingly active area of investigation, and recent studies suggest that mutations in cis-regulatory DNA can explain many inter-species differences in gene expression.
DOI: 
http://doi.org/10.1016/j.gde.2009.10.003
Research group: 
Odom Group
E-pub date: 
31 Dec 2009