Authors:
EM Serrao, TB Rodrigues, FA Gallagher, MI Kettunen, BWC Kennedy, SL Vowler, KA Burling, KM Brindle
Journal name: 
NMR Biomed
Citation info: 
29(8):1048-1055
Abstract: 
Imaging of the metabolism of hyperpolarized [1-(13) C]pyruvate has shown considerable promise in preclinical studies in oncology, particularly for the assessment of early treatment response. The repeatability of measurements of (13) C label exchange between pyruvate and lactate was determined in a murine lymphoma model in fasted and non-fasted animals. The fasted state showed lower intra-individual variability, although the [1-(13) C]lactate/[1-(13) C]pyruvate signal ratio was significantly greater in fasted than in non-fasted mice, which may be explained by the higher tumor lactate concentrations in fasted animals. These results indicate that the fasted state may be preferable for the measurement of (13) C label exchange between pyruvate and lactate, as it reduces the variability and therefore should make it easier to detect the effects of therapy. © 2016 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
DOI: 
http://doi.org/10.1002/nbm.3568
Research group: 
Brindle Group
E-pub date: 
31 Aug 2016