SA Rahman, SM Cuesta, N Furnham, GL Holliday, JM Thornton
Journal name: 
Nat Methods
Citation info: 
We present EC-BLAST (, an algorithm and Web tool for quantitative similarity searches between enzyme reactions at three levels: bond change, reaction center and reaction structure similarity. It uses bond changes and reaction patterns for all known biochemical reactions derived from atom-atom mapping across each reaction. EC-BLAST has the potential to improve enzyme classification, identify previously uncharacterized or new biochemical transformations, improve the assignment of enzyme function to sequences, and assist in enzyme engineering.
E-pub date: 
01 Feb 2014
Users with this publication listed: 
Sergio Martinez Cuesta