Authors:
N Martín-Pintado, M Yahyaee-Anzahaee, GF Deleavey, G Portella, M Orozco, MJ Damha, C González
Journal name: 
J Am Chem Soc
Citation info: 
135(14):5344-5347
Abstract: 
Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conformers, allowing NMR structural determination of this particularly significant nucleic acid structure. 2'F-arabinose substitution provides the greatest stabilization as a result of electrostatic (F-CH---O4') and pseudo-hydrogen-bond (F---H8) stabilizing interactions. In contrast, 2'F-rG substitution provokes a dramatic destabilization of the quadruplex structure due to unfavorable electrostatic repulsion between the phosphate and the 2'-F.
DOI: 
http://doi.org/10.1021/ja401954t
E-pub date: 
10 Apr 2013