Authors:
CK Kwok, G Marsico, S Balasubramanian
Journal name: 
Cold Spring Harb Perspect Biol
Citation info: 
10(7)
Abstract: 
SUMMARYRNA G-quadruplex (rG4) secondary structures are proposed to play key roles in fundamental biological processes that include the modulation of transcriptional, co-transcriptional, and posttranscriptional events. Recent methodological developments that include predictive algorithms and structure-based sequencing have enabled the detection and mapping of rG4 structures on a transcriptome-wide scale at high sensitivity and resolution. The data generated by these studies provide valuable insights into the potentially diverse roles of rG4s in biology and open up a number of mechanistic hypotheses. Herein we highlight these methodologies and discuss the associated findings in relation to rG4-related biological mechanisms.
DOI: 
http://doi.org/10.1101/cshperspect.a032284
Research group: 
Balasubramanian Group
E-pub date: 
02 Jul 2018