Authors:
DM Owens, FM Watt
Journal name: 
Nat Rev Cancer
Citation info: 
3(6):444-451
Abstract: 
The outer covering of the skin--the epidermis--is subject to sustained environmental assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost through differentiation, and only long-term epidermal residents, such as stem cells, accumulate the number of genetic hits that are necessary for tumour development. So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?
DOI: 
http://doi.org/10.1038/nrc1096
Research group: 
Watt Group
E-pub date: 
01 Jun 2003