Authors:
CH Kuo, J Xian, JD Brenton, K Franze, E Sivaniah
Journal name: 
Adv Mater
Citation info: 
24(45):6058
Abstract: 
Complex stiffness gradient substrates for the study of mechanotactic cell migration are developed by Easan Sivaniah, Kristian Franze, and co-workers on page 6059. Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 μm.
DOI: 
http://doi.org/10.1002/adma.201290273
Research group: 
Brenton Group
E-pub date: 
27 Nov 2012