Authors:
LM Mulligan, E Gardner, H Telenius, BA Ponder
Journal name: 
Genomics
Citation info: 
13(4):1347-1349
Abstract: 
Vinculin is a cytoskeletal protein component of adherens type cell junctions. The gene had been mapped to 10q11.2-qter. We have used a combination of physical and genetic mapping techniques to refine this localization. Hybridization of the vinculin cDNA probe, HV1, to a human-rodent somatic hybrid panel initially suggested a position of either 10q11.2 or 10q22.1-10q23. Genetic recombination mapping in three-generation families with multiple endocrine neoplasia type 2 (MEN2) indicated a position distal to D10S22 (10q21.1) in 10q22.1-10q23. This was confirmed by hybridization of the vinculin cDNA to flow-sorted translocation derivative chromosomes containing the q21-qter portion of chromosome 10. We conclude that the vinculin locus maps in 10q22.1-q23, distal to D10S22.
DOI: 
http://doi.org/10.1016/0888-7543(92)90066-2
Research group: 
Ponder Group
E-pub date: 
31 Aug 1992
Users with this publication listed: 
Bruce Ponder