Authors:
SE Whitham, G Murphy, P Angel, HJ Rahmsdorf, BJ Smith, A Lyons, TJ Harris, JJ Reynolds, P Herrlich, AJ Docherty
Journal name: 
Biochem J
Citation info: 
240(3):913-916
Abstract: 
A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved and that they are secreted as proenzymes. A putative zinc-binding site was identified by its homology with the zinc-chelating sequence of thermolysin. These sequences permitted the identification of: transin, a protein induced in rat fibroblasts either exposed to growth factors or transformed by oncogenic viruses, as the rat homologue of stromelysin, and XHF1, a protein induced in human fibroblasts after treatment with tumourigenic agents, as collagenase.
DOI: 
http://doi.org/10.1042/bj2400913
E-pub date: 
30 Nov 1986
Users with this publication listed: 
Gillian Murphy