Authors:
MG Dunlop, SE Dobbins, SM Farrington, AM Jones, C Palles, N Whiffin, A Tenesa, S Spain, P Broderick, L-Y Ooi, E Domingo, C Smillie, M Henrion, M Frampton, L Martin, G Grimes, M Gorman, C Semple, YP Ma, E Barclay, J Prendergast, J-B Cazier, B Olver, S Penegar, S Lubbe, I Chander, LG Carvajal-Carmona, S Ballereau, A Lloyd, J Vijayakrishnan, L Zgaga, I Rudan, E Theodoratou, Colorectal Tumour Gene Identification (CORGI) Consortium, JM Starr, I Deary, I Kirac, D Kovacević, LA Aaltonen, L Renkonen-Sinisalo, J-P Mecklin, K Matsuda, Y Nakamura, Y Okada, S Gallinger, DJ Duggan, D Conti, P Newcomb, J Hopper, MA Jenkins, F Schumacher, G Casey, D Easton, M Shah, P Pharoah, A Lindblom, T Liu, Swedish Low-Risk Colorectal Cancer Study Group, CG Smith, H West, JP Cheadle, COIN Collaborative Group, R Midgley, DJ Kerr, H Campbell, IP Tomlinson, RS Houlston
Journal name: 
Nat Genet
Citation info: 
44(7):770-776
Abstract: 
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
DOI: 
http://doi.org/10.1038/ng.2293
Research group: 
Jodrell Group
E-pub date: 
27 May 2012