Authors:
C Feig, DT Odom
Journal name: 
EMBO J
Citation info: 
32(24):3114-3115
Abstract: 
Cohesin is a conserved protein complex indispensible for proper cell division, because it secures sister-chromatid cohesion following DNA replication until segregation is required at the onset of anaphase. Recent studies have revealed functions beyond this, showing that cohesin binds to interphase chromatin regulating gene expression at select loci via long-range chromosomal interactions. In this issue of The EMBO Journal, Sofueva et al (2013) use a combination of chromatin conformation capture methods, classical FISH imaging, and loss-of-function studies to elegantly demonstrate how cohesin controls the 3D architectural organization of the genome.
DOI: 
http://doi.org/10.1038/emboj.2013.248
Research group: 
Odom Group
E-pub date: 
11 Dec 2013