Authors:
GR McInroy, E-A Raiber, S Balasubramanian
Journal name: 
Chem Commun (Camb)
Citation info: 
50(81):12047-12049
Abstract: 
The exquisite selectivity of chemical reactions enables the study of rare DNA bases. However, chemical modification of the genome can affect downstream analysis. We report a PCR bias caused by such modification, and exemplify a solution with the synthesis and characterization of a cleavable aldehyde-reactive biotinylation probe.
DOI: 
http://doi.org/10.1039/c4cc05107f
Research group: 
Balasubramanian Group
E-pub date: 
18 Oct 2014