Authors:
DA Tuveson, RH Carter, SP Soltoff, DT Fearon
Journal name: 
Science
Citation info: 
260(5110):986-989
Abstract: 
Antigen receptors on B and T lymphocytes transduce signals by activating nonreceptor protein tyrosine kinases (PTKs). A family of receptor PTKs contains kinase insert regions with the sequence tyrosine-X-X-methionine (where X is any amino acid) that when phosphorylated mediate the binding and activation of phosphatidylinositol 3-kinase (PI 3-kinase). The CD19 membrane protein of B cells enhances activation through membrane immunoglobulin M (mIgM) and was found to contain a functional analog of the kinase insert region. Ligation of mIgM induced phosphorylation of CD19 and association with PI 3-kinase. Thus, CD19 serves as a surrogate kinase insert region for mIgM by providing the means for PI 3-kinase activation by nonreceptor PTKs.
DOI: 
http://doi.org/10.1126/science.7684160
E-pub date: 
30 Apr 1993
Users with this publication listed: 
Doug Fearon
David Tuveson